Resistance to cytotoxic therapy: a speculative overview.

Abstract excerpt

While most recent studies have focused on the MDR1 gene and other similar types of multidrug resistance, two other phenomena (inhibition of the apoptotic pathway and regrowth resistance) have the potential for producing a much broader type of resistance to cytotoxic therapy. This speculative review discusses the potential contribution of these types of resistance and the possible interrelationships between the...

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