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Doxorubicin-DNA Adducts Induce a Non-Topoisomerase II–Mediated Form of Cell Death

1 May 2006

Abstract excerpt

Doxorubicin (Adriamycin) is one of the most commonly used chemotherapeutic drugs and exhibits a wide spectrum of activity against solid tumors, lymphomas, and leukemias. Doxorubicin is classified as a topoisomerase II poison, although other mechanisms of action have been characterized. Here, we show that doxorubicin-DNA adducts (formed by the coadministration of doxorubicin with non-toxic doses of...

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PMID: 16651442
DOI: 10.1158/0008-5472.can-05-3410

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