Article
Bioelectronic detection of point mutations using discrimination of the H63D polymorphism of the Hfe gene as a model.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Dec 2000
Umek R M, Lin S S, Chen Yp Y, Irvine B, Paulluconi G, Chan V, Chong Y, Cheung L, Vielmetter J, Farkas D H
Abstract excerpt
BACKGROUND: A bioelectronic detection platform has recently been developed that facilitates the detection and characterization of nucleic acids. The DNA chip platform is compatible with homogeneous assays because separate labeling and wash steps are not required. A one-step, bioelectronic detection assay was developed to genotype patient samples with respect to the H63D polymorphism of the Hfe gene, associated...
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