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Semiautomated Electrochemical Melting Curve Analysis Device for the Detection of an Osteoporosis Associated Single Nucleotide Polymorphism in Blood.

Analytical chemistry - 26 Sept 2023

Yenice Cansu Pinar, Chahin Nassif, Jauset-Rubio Miriam, Hall Matthew, Biggs Phil, Dimai Hans-Peter, Obermayer-Pietsch Barbara, Ortiz Mayreli, O'Sullivan Ciara K

Abstract excerpt

The detection of single nucleotide polymorphisms (SNPs) is of increasing importance in many areas including clinical diagnostics, patient stratification for pharmacogenomics, and advanced forensic analysis. In the work reported, we apply a semiautomated system for solid-phase electrochemical melting curve analysis (éMCA) for the identification of the allele present at a specific SNP site associated with an...

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PMID: 37713191
DOI: 10.1021/acs.analchem.3c01668
PMCID: PMC10534999

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