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Article

Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism

6 Feb 2001

Abstract excerpt

Hepatotropism is a prominent feature of hepatitis B virus (HBV) infection. Cell lines of nonhepatic origin do not independently support HBV replication. Here, we show that the nuclear hormone receptors, hepatocyte nuclear factor 4 and retinoid X receptor alpha plus peroxisome proliferator-activated receptor alpha, support HBV replication in nonhepatic cells by controlling pregenomic RNA synthesis, indicating...

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PMID: 11172038
DOI: 10.1073/pnas.98.4.1841

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