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Control of hepatitis B virus at the level of transcription

8 Jun 2010

Abstract excerpt

Hepatitis B virus (HBV) is tightly controlled by a number of noncytotoxic mechanisms. This control occurs within the host hepatocyte at different steps of the HBV replication cycle. HBV persists by establishing a nuclear minichromosome, HBV cccDNA, serving as a transcription template for the viral pregenome and viral mRNAs. Nucleoside/nucleotide analogues widely used for antiviral therapy as well as most...

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PMID: 20546497
DOI: 10.1111/j.1365-2893.2010.01315.x

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