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Article

Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1.

Journal of virology - 1 Feb 2003

Yu Xianming, Mertz Janet E

Abstract excerpt

To study the effects of the nuclear receptors (NRs) HNF4alpha and COUP-TF1 on the life cycle of hepatitis B virus (HBV), the human hepatoma cell line Huh7 was transiently cotransfected with plasmids containing the HBV genome and encoding these two NRs. Overexpression of HNF4alpha and COUP-TF1 led to a 9-fold increase and a 7- to 10-fold decrease, respectively, in viral DNA synthesis. These two NRs also exhibited...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B virus

Share to Hepatocyte Nuclear Factor 4

Share to Phosphoproteins

Share to Receptors, Cytoplasmic and Nuclear

Share to Response Elements

Share to Tumor Cells, Cultured

Source

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Identifiers

PMID: 12551987
DOI: 10.1128/jvi.77.4.2489-2499.2003
PMCID: PMC141100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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