Article
Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression.
The Journal of biological chemistry - 27 Feb 2015
Tsukuda Senko, Watashi Koichi, Iwamoto Masashi, Suzuki Ryosuke, Aizaki Hideki, Okada Maiko, Sugiyama Masaya, Kojima Soichi, Tanaka Yasuhito, Mizokami Masashi, Li Jisu, Tong Shuping, Wakita Takaji
Abstract excerpt
Sodium taurocholate cotransporting polypeptide (NTCP) is an entry receptor for hepatitis B virus (HBV) and is regarded as one of the determinants that confer HBV permissiveness to host cells. However, how host factors regulate the ability of NTCP to support HBV infection is largely unknown. We aimed to identify the host signaling that regulated NTCP expression and thereby permissiveness to HBV. Here, a cell-based...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.