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Article

A concerted action of HNF4α and HNF1α links hepatitis B virus replication to hepatocyte differentiation

11 Mar 2008

Abstract excerpt

Hepatitis B virus (HBV) is an important human pathogen, which targets the liver extremely efficient, gaining access to hepatocytes by a so far unknown receptor and replicating in a hepatocyte-specific fashion. Cell differentiation seems to determine HBV replication. We here show that the level of hepatocyte differentiation, as indicated by hepatocyte polarization and metabolic activity, is closely correlated to...

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Share to Hepatitis B Virus Studies
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PMID: 18346225
DOI: 10.1111/j.1462-5822.2008.01141.x

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