Article
APOE genotype is a major predictor of long-term progression of disability in MS.
Neurology - 13 Feb 2001
Chapman J, Vinokurov S, Achiron A, Karussis D M, Mitosek-Szewczyk K, Birnbaum M, Michaelson D M, Korczyn A D
Abstract excerpt
BACKGROUND AND OBJECTIVE: The authors recently reported that the APOE epsilon4 allele is associated with significantly greater progression of disability in a 2-year follow-up of patients with MS. In this study, these findings are substantiated and extended in a much larger group of patients followed for up to 40 years. METHODS: Two hundred five patients with clinically definite MS who were genotyped for the APOE...
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