Article
Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Mar 2001
Ramakrishna R, Edwards J S, McCulloch A, Palsson B O
Abstract excerpt
Mitochondrial metabolism is a critical component in the functioning and maintenance of cellular organs. The stoichiometry of biochemical reaction networks imposes constraints on mitochondrial function. A modeling framework, flux-balance analysis (FBA), was used to characterize the optimal flux distributions for maximal ATP production in the mitochondrion. The model predicted the expected ATP yields for glucose,...
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