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Article

Impact of stoichiometry representation on simulation of genotype-phenotype relationships in metabolic networks.

PLoS computational biology - 1 Jan 2012

Brochado Ana Rita, Andrejev Sergej, Maranas Costas D, Patil Kiran R

Abstract excerpt

Genome-scale metabolic networks provide a comprehensive structural framework for modeling genotype-phenotype relationships through flux simulations. The solution space for the metabolic flux state of the cell is typically very large and optimization-based approaches are often necessary for predicting the active metabolic state under specific environmental conditions. The objective function to be used in such...

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PMID: 23133362
DOI: 10.1371/journal.pcbi.1002758
PMCID: PMC3486866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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