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Evaluating proteome allocation of Saccharomyces cerevisiae phenotypes with resource balance analysis.

Metabolic engineering - 1 May 2023

Dinh Hoang V, Maranas Costas D

Abstract excerpt

Saccharomyces cerevisiae is an important model organism and a workhorse in bioproduction. Here, we reconstructed a compact and tractable genome-scale resource balance analysis (RBA) model (i.e., named scRBA) to analyze metabolic fluxes and proteome allocation in a computationally efficient manner. Resource capacity models such as scRBA provide the quantitative means to identify bottlenecks in biosynthetic...

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PMID: 37080482
DOI: 10.1016/j.ymben.2023.04.009

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