Article
Novel immunoassay for the detection of hepatitis B surface 'escape' mutants and its application in liver transplant recipients.
Journal of medical virology - 1 Mar 2001
Ijaz S, Torre F, Tedder R S, Williams R, Naoumov N V
Abstract excerpt
Hepatitis B virus (HBV) strains with mutations in the surface gene are responsible for the failure of prophylaxis with hepatitis B immunoglobulin (HBIG) in a proportion of patients transplanted for HBsAg positive cirrhosis. So far, the emergence and evolution of these 'surface antibody escape' mutants have been studied by DNA sequencing. In this study the use of an immunoassay is described for diagnosis and...
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