Article
Detection of a premature stop codon in the surface gene of hepatitis B virus from an HBsAg and antiHBc negative blood donor.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Nov 2007
Datta Sibnarayan, Banerjee Arup, Chandra Partha K, Chakraborty Subhasis, Basu Subir Kumar, Chakravarty Runu
Abstract excerpt
BACKGROUND: In blood donors, HBV infection is detected by the presence of serum hepatitis B surface antigen (HBsAg). However, some mutations in the surface gene region may result in altered or truncated HBsAg that can escape from immunoassay-based diagnosis. Such diagnostic escape mutants pose a...
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