A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro.

doi:10.3390/v12020251

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Article

A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro.

Viruses - 23 Feb 2020

Salpini Romina, Piermatteo Lorenzo, Battisti Arianna, Colagrossi Luna, Aragri Marianna, Yu La Rosa Katia, Bertoli Ada, Saccomandi Patrizia, Lichtner Miriam, Marignani Massimo, Maylin Sarah, Delaugerre Constance, Morisco Filomena, Coppola Nicola, Marrone Aldo, Iapadre Nerio, Cerva Carlotta, Aquaro Stefano, Angelico Mario, Sarmati Loredana, Andreoni Massimo, Verheyen Jens, Ceccherini-Silberstein Francesca, Levrero Massimo, Perno Carlo Federico, Belloni Laura, Svicher Valentina

Abstract excerpt

Immune-suppression driven Hepatitis B Virus (HBV)-reactivation poses serious concerns since it occurs in several clinical settings and can result in severe forms of hepatitis. Previous studies showed that HBV strains, circulating in patients with HBV-reactivation, are characterized by an enrichment of immune-escape mutations in HBV surface antigen (HBsAg). Here, we focused on specific immune-escape mutations...

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Identifiers

PMID: 32102257
DOI: 10.3390/v12020251
PMCID: PMC7077195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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