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Article

Alphaherpesviral US3 kinase induces cofilin dephosphorylation to reorganize the actin cytoskeleton.

Journal of virology - 1 Apr 2013

Jacob Thary, Van den Broeke Céline, van Troys Marleen, Waterschoot Davy, Ampe Christophe, Favoreel Herman W

Abstract excerpt

The conserved alphaherpesviral serine/threonine kinase US3 causes dramatic actin rearrangements, associated with increased viral spread. Here, we show that US3 of pseudorabies virus (PRV) leads to activation (dephosphorylation) of the central actin regulator cofilin. A mutation that impairs US3 kinase activity and the group I p21-activated kinase inhibitor IPA-3 inhibited US3-mediated cofilin activation....

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Share to Actin Cytoskeleton
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23365433
DOI: 10.1128/JVI.03107-12
PMCID: PMC3624233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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