Article
The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 1997
Leopardi R, Van Sant C, Roizman B
Abstract excerpt
An earlier report showed that a disabled mutant lacking both copies of the major regulatory gene (alpha4) of herpes simplex virus 1 induced DNA degradation characteristic of apoptosis in infected cells, whereas the wild-type virus protected cells from apoptosis induced by thermal shock. More extensive analyses of the disabled mutant revealed a second mutation which disabled US3, a viral gene encoding a protein...
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