Article
The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 1997
Leopardi R, Van Sant C, Roizman B
Abstract excerpt
An earlier report showed that a disabled mutant lacking both copies of the major regulatory gene (alpha4) of herpes simplex virus 1 induced DNA degradation characteristic of apoptosis in infected cells, whereas the wild-type virus protected cells from apoptosis induced by thermal shock. More exte...
Topics
- Animals
- Apoptosis
- Cell Line
- Chlorocebus aethiops
- Cricetinae
- Genes, Viral
- Herpesvirus 1, Human
- Humans
- Immediate-Early Proteins
- Mutation
- Phosphorylation
- Protein Serine-Threonine Kinases
- Vero Cells
- Viral Proteins