Article
Role of the electrostatic loop of Cu,Zn superoxide dismutase in the copper uptake process.
European journal of biochemistry - 1 Feb 2001
Ciriolo M R, Battistoni A, Falconi M, Filomeni G, Rotilio G
Abstract excerpt
Cu,Zn superoxide dismutases are characterized by the presence of four highly conserved charged residues (Lys120, Glu/Asp130, Glu131 and Lys134), which are placed at the edge of the active site channel and have been shown to be individually involved in the electrostatic attraction of the substrate toward the catalytically active copper ion. By genetic engineering we mutated these four residues into neutrally...
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