Article
Design of fast enzymes by optimizing interaction potential in active site.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 1997
Zhou H X, Wong K Y, Vijayakumar M
Abstract excerpt
The diffusional encounter between substrate and enzyme, and hence catalytic efficiency, can be enhanced by mutating charged residues on the surface of the enzyme. In this paper we present a simple method for screening such mutations. This is based on our earlier result that electrostatic enhancem...
Topics
- Animals
- Binding Sites
- Drug Design
- Enzymes
- Humans
- Molecular Structure
- Mutation
- Static Electricity
- Superoxide Dismutase