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Article

Design of fast enzymes by optimizing interaction potential in active site.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 1997

Zhou H X, Wong K Y, Vijayakumar M

Abstract excerpt

The diffusional encounter between substrate and enzyme, and hence catalytic efficiency, can be enhanced by mutating charged residues on the surface of the enzyme. In this paper we present a simple method for screening such mutations. This is based on our earlier result that electrostatic enhancement of the enzyme-substrate binding rate constant can be accounted for just by the interaction potential within the...

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Identifiers

PMID: 9356456
DOI: 10.1073/pnas.94.23.12372
PMCID: PMC24950

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Source receipt: pubmed, retrieved 7 Sept 2026.

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