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Article

Mechanistic insights into the superoxide-cytochrome c reaction by lysine surface scanning.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry - 1 Apr 2013

Wegerich Franziska, Giachetti Andrea, Allegrozzi Marco, Lisdat Fred, Turano Paola

Abstract excerpt

This study summarizes results which have been obtained by a mutational study of human cytochrome c. The protein can be used as a recognition element in analytical assays and biosensors for superoxide radicals since ferricytochrome c reacts with superoxide to form ferrocytochrome c and oxygen. Here lysine mutagenesis of the distal surface (i.e., of exposed residues around the Met80 axial ligand) of human...

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PMID: 23455484
DOI: 10.1007/s00775-013-0987-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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