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Article

Single mutation at the intersubunit interface confers extra efficiency to Cu,Zn superoxide dismutase.

FEBS letters - 13 Oct 2000

Stroppolo M E, Pesce A, Falconi M, O'Neill P, Bolognesi M, Desideri A

Abstract excerpt

The Val28-->Gly single mutant at the subunit interface of Cu,Zn superoxide dismutase from Photobacterium leiognathi displays a k(cat)/K(M) value of 1.7x10(10) M(-1) s(-1), twice that of the native enzyme. Analysis of the three-dimensional structure indicates that the active site Cu,Zn center is not perturbed, slight structural deviations being only localized in proximity of the mutation site. The enzyme-substrate...

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PMID: 11033348
DOI: 10.1016/s0014-5793(00)01967-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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