Article
Molecular dynamics studies on mutants of Cu,Zn superoxide dismutase: the functional role of charged residues in the electrostatic loop VII.
Proteins - 1 Mar 1994
Banci L, Carloni P, Orioli P L
Abstract excerpt
Molecular dynamics (MD) calculations have been performed on mutants of superoxide dismutase (SOD) on some residues present in the electrostatic loop. These calculations have provided the solution structures for the mutants Thr-137-->Ile and Arg; Lys-136-->Ala; Glu-132-->Gln; Glu-133-->Gln; Glu-132, Glu-133-->Gln-132, Gln-133 and-->Gln-132, Lys-133. The structural and dynamic properties of these mutants have been...
Topics
- Binding Sites
- Computer Simulation
- Copper
- Electricity
- Hydrogen Bonding
- Models, Molecular
- Mutation
- Protein Conformation
- Superoxide Dismutase
- Water