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Article

CRM1- and Ran-independent nuclear export of beta-catenin.

Current biology : CB - 9 Jan 2001

Wiechens N, Fagotto F

Abstract excerpt

BACKGROUND: Activation of the Wnt pathway induces beta-catenin to localize inside the nucleus, where it interacts with transcription factors such as TCF/LEF-1. Regulation of the pathway occurs through a beta-catenin-degrading complex based on Axin and the tumor suppressor APC. We have previously found that beta-catenin import occurs independently of nuclear import factors but is similar to the import of the...

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Identifiers

PMID: 11166175
DOI: 10.1016/s0960-9822(00)00045-2

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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