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Article

Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells.

Cell biology international - 1 Mar 2006

Ki Hyunkyoung, Jung Ho-Chul, Park Jae-Hyo, Kim Jin-Sook, Lee Kwang Youl, Kim Tae Sung, Kim Kwonseop

Abstract excerpt

Beta-catenin not only plays a role in cadherin-dependent cell adhesion, but also interacts with T-cell factor (TCF)/lymphoid enhancer factor-1 (LEF-1) to affect gene expression. In this report, we describe the effects of exogenous LEF-1 and of treatment with leptomycin B (LMB), a specific inhibitor of CRM1-medicated nuclear export, on the nuclear localization and export of beta-catenin. Normal epithelial cells...

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Identifiers

PMID: 16378739
DOI: 10.1016/j.cellbi.2005.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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