Article
Involvement of CRM1, a nuclear export receptor, in mRNA export in mammalian cells and fission yeast.
Genes to cells : devoted to molecular & cellular mechanisms - 1 May 1999
Watanabe M, Fukuda M, Yoshida M, Yanagida M, Nishida E
Abstract excerpt
BACKGROUND: CRM1, an evolutionarily conserved protein, was shown to be a receptor for leucine-rich nuclear export signal (NES)-dependent protein transport. In lower eukaryotes CRM1 is reported to be required for the export of mRNA, however, involvement of the NES-dependent transport pathway in mRNA export in higher eukaryotes has not been established. RESULTS: We have found that treatment of mammalian cells with...
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