Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of β-catenin nuclear dynamics by GSK-3β involves a LEF-1 positive feedback loop.

Traffic (Copenhagen, Denmark) - 1 Aug 2011

Jamieson Cara, Sharma Manisha, Henderson Beric R

Abstract excerpt

Nuclear localization of β-catenin is integral to its role in Wnt signaling and cancer. Cellular stimulation by Wnt or lithium chloride (LiCl) inactivates glycogen synthase kinase-3β (GSK-3β), causing nuclear accumulation of β-catenin and transactivation of genes that transform cells. β-catenin is a shuttling protein; however, the mechanism by which GSK-3β regulates β-catenin nuclear dynamics is poorly understood....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Glycogen Synthase Kinase 3
Share to Glycogen Synthase Kinase 3 beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lithium Chloride

Share to Lymphoid Enhancer-Binding Factor 1

Share to NIH 3T3 Cells

Share to Transcriptional Activation

Share to Wnt Proteins

Source

Identifiers

PMID: 21496192
DOI: 10.1111/j.1600-0854.2011.01207.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of β-catenin nuclear dynamics by GSK-3β involves a LEF-1 positive feedback loop.PMID 21496192Read ↗

The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3beta.Semantic proximity Read ↗

Beta-catenin can act as a nuclear import receptor for its partner transcription factor, lymphocyte enhancer factor-1 (lef-1).Semantic proximity Read ↗

Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics.Semantic proximity Read ↗

Wnt target gene activation requires β-catenin separation into biomolecular condensates.Semantic proximity Read ↗

β-catenin-mediated activation of Wnt target genes utilizes a biomolecular condensate-dependent mechanismSemantic proximity Read ↗

CRM1- and Ran-independent nuclear export of beta-catenin.Semantic proximity Read ↗

Kinase-Inactive Glycogen Synthase Kinase 3β Promotes Wnt Signaling and Mammary TumorigenesisSemantic proximity Read ↗

Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells.Semantic proximity Read ↗

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cellsSemantic proximity Read ↗

Induction of Gsk3β-β-TrCP interaction is required for late phase stabilization of β-catenin in canonical Wnt signaling.Semantic proximity Read ↗

p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions.Semantic proximity Read ↗

Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.