Adaptive mutations in Escherichia coli as a model for the multiple mutational origins of tumors.

Abstract excerpt

The cells in most tumors are found to carry multiple mutations; however, based upon mutation rates determined by fluctuation tests, the frequency of such multiple mutations should be so low that tumors are never detected within human populations. Fluctuation tests, which determine the cell-division-dependent mutation rate per cell generation in growing cells, may not be appropriate for estimating mutation rates...

Topics

• Adaptation, Physiological
• Escherichia coli
• Mutation
• Neoplasms