Article
Spontaneous mutagenesis assay.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Blackwell Susan, Hanna Michelle D, Xiao Wei
Abstract excerpt
Spontaneous mutations occur in the DNA as a result of endogenous cellular processes. The antimutagenic processes within a cell consist primarily of mechanisms of DNA repair, which are critical for maintenance of genomic stability, while mutagenic processes include mistakes by the replicative machinery and spontaneous alterations in the base chemistry of DNA. In Saccharomyces cerevisiae spontaneous mutagenesis...
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