Article
Startle responses, heart rate, and temperature in 5-HT1B receptor knockout mice.
Neuroreport - 18 Dec 2000
Bouwknecht J A, Hijzen T H, van der Gugten J, Dirks A, Maes R A, Hen R, Geyer M A, Olivier B
Abstract excerpt
Relative to wildtype mice, mice lacking 5-HT1B receptors (5-HT1B KO) exhibit exaggerated heart rate and body temperature responses to environmental stimuli. In contrast, acoustic startle reactivity is reduced in 5-HT1B KO mice. We combined heart rate and temperature measurement with startle response paradigms in order to elucidate this apparent contradiction. Habituation and footshock-induced sensitization...
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