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Article

Increased fear response to contextual cues in mice lacking the 5-HT1A receptor.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2006

Klemenhagen Kristen C, Gordon Joshua A, David Denis J, Hen René, Gross Cornelius T

Abstract excerpt

Serotonin 1A receptor knockout (5-HT1AR KO) mice exhibit increased behavioral inhibition in conflict tests. To gain further insight into their anxiety-related phenotype, we subjected these mice to additional behavioral tests. First, we considered whether behavioral inhibition in these knockout mice is a consequence of reduced exploratory motivation. The knockout mice engage in normal exploration during a...

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Share to Receptor, Serotonin, 5-HT1A

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Identifiers

PMID: 15920501
DOI: 10.1038/sj.npp.1300774

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