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Article

Regulating the neoplastic phenotype using engineered transcriptional repressors.

Cancer letters - 1 Jan 2001

Fredericks W J, Ayyanathan K, Rauscher F J

Abstract excerpt

We have applied engineered transcriptional repressors to specifically inhibit disease gene-activated pathways in oncogenesis. We have demonstrated that synthetic repressors combining PAX3 DNA binding domains with different repression domains, KRAB or SNAG, are able to specifically inhibit malignant growth and suppress tumorigenesis in alveolar rhabdomyosarcoma tumor cells transformed by the translocation-derived...

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Source

Identifiers

PMID: 11164187
DOI: 10.1016/s0304-3835(00)00649-2

Genes

PAX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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