Article
NFκB signaling in alveolar rhabdomyosarcoma.
Disease models & mechanisms - 1 Sept 2017
Cleary Megan M, Mansoor Atiya, Settelmeyer Teagan, Ijiri Yuichi, Ladner Katherine J, Svalina Matthew N, Rubin Brian P, Guttridge Denis C, Keller Charles
Abstract excerpt
Alveolar rhabdomyosarcoma (aRMS) is a pediatric soft tissue cancer commonly associated with a chromosomal translocation that leads to the expression of a Pax3:Foxo1 or Pax7:Foxo1 fusion protein, the developmental underpinnings of which may give clues to its therapeutic approaches. In aRMS, the NFκB-YY1-miR-29 regulatory circuit is dysregulated, resulting in repression of miR-29 and loss of the associated tumor...
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