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Article

Mutations, methylation and expression of CDKN2a/p16 gene in colorectal cancer and normal colonic mucosa.

Cancer letters - 10 Feb 2001

Trzeciak L, Hennig E, Kolodziejski J, Nowacki M, Ostrowski J

Abstract excerpt

The status of CDKN2a gene, coding for p16 and p19ARF proteins, was examined in 55 colorectal cancers. Polymerase chain reaction (PCR), single stranded conformational polymorphism and sequencing revealed 1 case of CDKN2a mutation. Methylation-specific PCR detected p16 locus methylation in 37 (73%) of 51 normal samples and 29 (53%) of 55 cancers (P=0.035). p16 transcript absence (assessed by reverse...

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PMID: 11163104
DOI: 10.1016/s0304-3835(00)00652-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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