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Article

p16 gene methylation in colorectal cancer patients with long-term follow-up

1 Mar 2012

Abstract excerpt

INTRODUCTION: p16 gene plays an important role in the cell cycle regulation and is considered an important tumor suppressor gene. Several mechanisms of gene inactivation have been described; in this study we have focused on p16 gene promoter methylation. In colorectal cancer p16 gene methylation is a frequent event. METHODS: 326 patients with sporadic colorectal cancer were included. DNA was extracted from tumor...

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PMID: 22449151
DOI: 10.4321/s1130-01082012000300002

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