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Article

O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis.

Oncology reports - 1 Jun 2007

Menigatti Mirco, Pedroni Monica, Verrone Anna Maria, Borghi Francesca, Scarselli Alessandra, Benatti Piero, Losi Lorena, Di Gregorio Carmela, Schär Primo, Marra Giancarlo, Ponz de Leon Maurizio, Roncucci Luca

Abstract excerpt

Epigenetic alterations have been reported in colorectal neoplasia which can either complement or in some cases be predisposed to genetic alterations such as K-ras mutations. We examined the promoter methylation status of the CDKN2A and O6-methylguanine-DNA methyltransferase (MGMT) genes, after sodium bisulfite conversion and DNA amplification with methylation specific PCR. Moreover, we searched for G to A...

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Identifiers

PMID: 17487400

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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