Article
DES action in the thymus: inhibition of cell proliferation and genetic variation.
Molecular and cellular endocrinology - 22 Dec 2000
Gould K A, Shull J D, Gorski J
Abstract excerpt
Many tissues, including the thymus, represent direct targets of estrogen action. In contrast to many estrogen responsive tissues, the thymus undergoes a profound atrophy in response to elevated levels of estrogens. The mechanism of estrogen-induced atrophy in the thymus is unknown; however, it appears not to involve massive thymocyte apoptosis. Here, we demonstrate that the estrogen diethylstilbestrol (DES)...
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