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Article

Sex steroid blockade enhances thymopoiesis by modulating Notch signaling

20 Oct 2014

Abstract excerpt

Paradoxical to its importance for generating a diverse T cell repertoire, thymic function progressively declines throughout life. This process has been at least partially attributed to the effects of sex steroids, and their removal promotes enhanced thymopoiesis and recovery from immune injury. We show that one mechanism by which sex steroids influence thymopoiesis is through direct inhibition in cortical thymic...

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Identifiers

PMID: 25332287
DOI: 10.1084/jem.20131289

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