Article
Identification of a cis-acting element and a novel trans-acting factor of the human insulin receptor gene in HepG2 and rat liver cells.
Biochemical and biophysical research communications - 19 Jan 2001
Yoshizato K, Shirotani T, Furukawa N, Taguchi T, Motoshima H, Toyonaga T, Hirashima Y, Kawashima J, Ebina Y, Shichiri M, Araki E
Abstract excerpt
The liver is a major target organ of insulin and is important for glucose homeostasis. We analyzed the tissue specific regulation of the insulin receptor gene in the liver by studying the cis-acting element and trans-acting factor of the human insulin receptor gene in human hepatoma cell line, HepG2 cells. In the chloramphenicol acetyl transferase (CAT) assay with chimeric plasmids containing various deletions...
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