Article
The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion.
Experimental cell research - 1 Feb 2001
Singh N, Talalayeva Y, Tsiper M, Romanov V, Dranovsky A, Colflesh D, Rudamen G, Vitek M P, Shen J, Yang X, Goldgaber D, Schwarzman A L
Abstract excerpt
Most cases of familial early-onset Alzheimer's disease are caused by mutations in the presenilin 1 (PS1) gene. However, the cellular functions of PS1 are unknown. We showed predominant localization of PS1 to cell-cell contacts of the plasma membrane in human prostate epithelial tissue and in a human epithelial cell line HEp2 stably transfected with an inducible PS1 construct. PS1 co-immunoprecipitated with...
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