Article
A conserved role for L1 as a transmembrane link between neuronal adhesion and membrane cytoskeleton assembly.
Cell adhesion and communication - 1 Jan 1998
Hortsch M, O'Shea K S, Zhao G, Kim F, Vallejo Y, Dubreuil R R
Abstract excerpt
The L1-family of cell adhesion molecules is involved in many important aspects of nervous system development. Mutations in the human L1-CAM gene cause a complicated array of neurological phenotypes; however, the molecular basis of these effects cannot be explained by a simple loss of adhesive function. Human L1-CAM and its Drosophila homolog neuroglian are rather divergent in sequence, with the highest degree of...
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