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Article

Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.

Journal of neurochemistry - 1 Jun 2010

Han Ina, You YiMei, Kordower Jeffrey H, Brady Scott T, Morfini Gerardo A

Abstract excerpt

Abnormal expansion of a polyglutamine tract in huntingtin (Htt) protein results in Huntington's disease (HD), an autosomal dominant neurodegenerative disorder involving progressive loss of motor and cognitive function. Contrasting with the ubiquitous tissue expression of polyglutamine-expanded Htt, HD pathology is characterized by the increased vulnerability of specific neuronal populations within the striatum...

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Identifiers

PMID: 20236390
DOI: 10.1111/j.1471-4159.2010.06672.x
PMCID: PMC2890032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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