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Article

Inferred hepatitis C virus quasispecies diversity is influenced by choice of DNA polymerase in reverse transcriptase-polymerase chain reactions.

Analytical biochemistry - 15 Feb 2001

Mullan B, Kenny-Walsh E, Collins J K, Shanahan F, Fanning L J

Abstract excerpt

The hepatitis C virus (HCV) is known to circulate in vivo as a quasispecies, a population of closely related, but genetically nonidentical virions. HCV reverse transcriptase (RT)-(nested) polymerase chain reaction (PCR) strategies are used to study quasispecies diversity at certain important viral genetic loci, predominantly at hypervariable region 1 (HVR 1) of the E2 envelope gene, and the interferon sensitivity...

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Share to DNA, Complementary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 11161307
DOI: 10.1006/abio.2000.4946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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