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Article

Analysis of fission yeast primase defines the checkpoint responses to aberrant S phase initiation.

Molecular and cellular biology - 1 Nov 2000

Tan S, Wang T S

Abstract excerpt

To investigate the checkpoint response to aberrant initiation, we analyzed the cell cycle checkpoint response induced by mutations of Schizosaccharomyces pombe DNA primase. DNA primase has two subunits, Spp1 and Spp2 (S. pombe primases 1 and 2). Spp1 is the catalytic subunit that synthesizes the RNA primer, which is then extended by DNA polymerase alpha (Polalpha) to synthesize an initiation DNA structure, and...

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Identifiers

PMID: 11027257
DOI: 10.1128/MCB.20.21.7853-7866.2000
PMCID: PMC86397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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