Article
Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line.
BMC cancer - 21 Nov 2011
Singh Gobind, Odriozola Leticia, Guan Hong, Kennedy Colin R, Chan Andrew M
Abstract excerpt
BACKGROUND: Cowden Syndrome (CS) patients with germ line point mutations in the PTEN gene are at high risk for developing breast cancer. It is believed that cells harboring these mutant PTEN alleles are predisposed to malignant conversion. This article will characterize the biochemical and biological properties of a mutant PTEN protein found in a commonly used metastatic breast cancer cell line. METHODS: The...
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