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The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer.

Pharmacogenetics - 1 Jul 2002

Spurdle Amanda B, Goodwin Bryan, Hodgson Ecushla, Hopper John L, Chen Xiaoqing, Purdie David M, McCredie Margaret R E, Giles Graham G, Chenevix-Trench Georgia, Liddle Christopher

Abstract excerpt

CYP3A4 is involved in the metabolism of endogenous steroids, and an allelic variant, CYP3A4*1B, consisting of an A to G polymorphism within the 5'-flanking region termed the nifedipine-specific response element (NFSE) has been associated with high grade and advanced stage of prostate cancers. Because steroid hormone exposure is known to influence breast and ovarian cancer risk, we conducted case-control studies...

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PMID: 12142725
DOI: 10.1097/00008571-200207000-00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer.PMID 12142725Read ↗

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