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Article

Targeted deletion of <i>Smad4</i> shows it is required for transforming growth factor β and activin signaling in colorectal cancer cells

3 Mar 1998

Abstract excerpt

Smad4 (DPC4) is a candidate tumor suppressor gene that has been hypothesized to be critical for transmitting signals from transforming growth factor (TGF) beta and related ligands. To directly test this hypothesis, the Smad4 gene was deleted through homologous recombination in human colorectal cancer cells. This deletion abrogated signaling from TGF-beta, as well as from the TGF-beta family member activin. These...

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PMID: 9482899
DOI: 10.1073/pnas.95.5.2412

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