Article
Dpc4 transcriptional activation and dysfunction in cancer cells.
Cancer research - 15 Oct 1998
Dai J L, Turnacioglu K K, Schutte M, Sugar A Y, Kern S E
Abstract excerpt
Dpc4 (Smad4) is implicated in mediation of signals from transforming growth factor (TGF) beta and related ligands, and wild-type Dpc4 mediates TGF-beta-stimulated gene transcription at specific DNA sequences bound by Dpc4 [Smad binding element (SBE)]. We characterized panels of DPC4 tumor mutatio...
Topics
- DNA
- DNA-Binding Proteins
- Humans
- Mutation
- Neoplasms
- Smad4 Protein
- Structure-Activity Relationship
- Trans-Activators
- Transcriptional Activation
- Transforming Growth Factor beta
- Tumor Cells, Cultured