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Article

Smad4/DPC4.

Journal of clinical pathology - 1 Aug 2018

McCarthy Aoife J, Chetty Runjan

Abstract excerpt

Smad4 or DPC4 belongs to a family of signal transduction proteins that are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor beta (TGF-β) signaling via several pathways. The gene acts as a tumour suppressor gene and inactivation of smad4/DPC4 is best recognised in pancreatic cancer. However, smad4/DPC4 is also mutated in other conditions and...

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Identifiers

PMID: 29720405
DOI: 10.1136/jclinpath-2018-205095

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