Article
A triclosan-ciprofloxacin cross-resistant mutant strain of Staphylococcus aureus displays an alteration in the expression of several cell membrane structural and functional genes.
Research in microbiology - 1 Jan 2000
Tkachenko Olga, Shepard Jessica, Aris Virginie M, Joy Amy, Bello Anangely, Londono Indira, Marku Jehona, Soteropoulos Patricia, Peteroy-Kelly Marcy A
Abstract excerpt
Triclosan is an antimicrobial agent found in many consumer products. Triclosan inhibits the bacterial fatty acid biosynthetic enzyme, enoyl-ACP reductase (FabI). Decreased susceptibility to triclosan correlates with ciprofloxacin resistance in several bacteria. In these bacteria, resistance to both drugs maps to genes encoding multi-drug efflux pumps. The focus of this study was to determine whether triclosan...
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